Most of my research hinges on the analysis of ‘big data’. I have terabytes of DNA and RNA sequence data that I am analyzing, and the analysis of that much data requires a powerful computer with a whole lot of RAM. Many people use supercomputers, which are like many powerful computers hooked up together, but there is often a long queue to use the computing resources, meaning that you may have to wait a while for everyone else to finish up using the supercomputer before your data can be run. Supercomputers are also a bit more complicated to use because you have to submit a job and you can’t just run your programs like you would on your own computer.
Since so much of my research requires these sophisticated computers, I’ve decided to build myself a computer! I thought it might be useful to some other scientists if I share my experiences choosing computer parts and then putting them together to make a sophisticated data-crunching machine!
The first step to building a computer is of course choosing the parts.
The first thing to decide is how much random-access memory (RAM) you want. RAM is what programs use to store data not saved in files, such as temporary information. In DNA analysis, how much RAM you have is very important because often you need to compare many sequences to find matches, and all of the potential matches are stored using RAM. The most RAM you can get before having to upgrade to a server instead of a desktop is 64 GB (which is a lot). For my lab computer, I went with 64 GB, but for my own personal computer I chose 32 GB, but left room to upgrade if I wanted to (i.e. I chose 4 x 8GB RAM, leaving an additional 4 slots available if I want them).
Once you’ve decide how much RAM you want, you need to decide what type of RAM. Technology is constantly changing, and there is a ‘new’ type of RAM available: DDR4 (as opposed to DDR3). DDR4 is faster but more expensive, so there’s a tradeoff there. I chose to go with DDR4, but DDR3 should work just as well.
Choosing a brand can be confusing, because there are so many companies out there! I went with G.SKILL Ripjaws series RAM because it came well-recommended from more experienced computer builders.
The core processing unit (CPU) is the next component to choose. This is where most of your computer’s power comes from. The type and amount of memory you chose will determine what type of CPU you can get. Intel is generally the CPU brand of choice, and at the moment their cutting-edge CPU model is the Intel i7. To match my desired 64 GB of RAM, I needed a LGA2011-v3 socket type, so that narrowed down my search to three types. Because I’m price-sensitive, I chose the Intel i7 5820k.
Once the CPU is picked out, you can choose a motherboard. I did most of my searching for parts on newegg.com, because you can narrow your search results based on the things you want. For instance, since I chose an Intel CPU, I searched “intel motherboard” and then clicked the box for “LGA2011-vs” and under “Maximum Memory Supported” I chose “64GB”. Then I looked through the other specifications I might be interested in (number of ports, expansion slots, etc.) and again asked other people about brands that are good, and I wound up going with the Asus X99 series of motherboards.
One thing to note is that reviews of motherboards are invariably going to be on average middle of the road. This is because there will always be some cases where the hardware is defective, regardless of the company, and those reviews will drag the average rating down.
Once you’ve chosen your RAM, CPU, and motherboard, choosing the rest of your components doesn’t need to happen in any particular order. You just want to make sure everything is compatible. I recommend using pcpartpicker.com to check compatibility of the components you choose.
4. Storage Size and Type
The first major decision you need to make is whether you want to run your operating system off of a solid-state hard drive. Solid state drives don’t have moving pieces like traditional spinning hard drives, but they are quite pricey in comparison. The main benefit is that they allow you to start up your operating system and programs much more quickly and are less prone to mechanical failures. I chose to go without one for my personal computer build, although I’ve got one in my lab computer and love the speed.
Then you need to decide how many other hard drives you want and how much storage space you want. I chose two 4 TB hard drives because my data takes up a lot of storage space, but that becomes a personal decision about how much you need to store and price.
5. Power supply
A necessary component of any computer is the power supply unit (PSU). The EVGA brand was recommended to me, and I chose to go with an 850W PSU because I might need quite a bit of power to run all of my analyses.
6. Graphics card
A graphics card is necessary to run the computer’s display. To choose a graphics card, look at your motherboard’s specifications to see what type(s) and how many PCI slots it has to narrow down your search results. For data analysis you don’t need a particularly fancy graphics card with a bunch of overclocking ability like you would if you were building a gaming computer. The EVGA brand was recommended to me, so I chose based on compatibility, brand, and price.
7. CPU Cooler
This is an important choice. Since I will be working my CPU pretty hard, I chose to go with a dual-fan CPU cooler, the Cooler Master Hpyer D92.
The case is important. You want one big enough to fit all of your components and have a bit of breathing room, so I recommend a mid-tower design. I also chose one that came with several built-in fans and a couple of USB slots on the front. These cases can get pretty fancy, so as long as it fits your motherboard and has enough space to keep your computer cool, you can probably choose based on extra features and coolness factor (how many LED-lighted fans do you want?)
9. Wireless adapter
Some motherboards come with on-board wifi, but if yours doesn’t you may want to buy a WiFi adapter.
10. CD/DVD Drive
This is a purely optional component. Having an optical drive will help you install the drivers that come with all of your components, but it is not necessary
11. Accessories: Keyboard, mouse, monitor
I’m pretty happy with a standard wired mouse and keyboard, so I went for the cheap Microsoft set. But I did spring for a nice 27″ monitor. These things, and others (speakers etc) are completely up to your personal preferences.
Important Tip: Shop around!!
There are many retailers selling computer parts, and some have different promotions going on at different times. newegg.com is usually pretty low-priced, but I recommend also checking TigerDirect.com, Best Buy, ncixus.com, and Amazon. I bought almost all of my components from Newegg, because it was the cheapest, but I did get a couple of items from other vendors.
If you’re having trouble deciding on components, read reviews, watch Youtube videos, and talk to experienced computer-builders. It can be overwhelming but I learned a lot about how computers work just by shopping around for the various components.
For how to put the pieces together, check out Part 2: Putting the Pieces Together!